MolNFT v1 · #3346 · protein

Structure of carboxypeptidase B at 2.8 ångströms resolution

1CPB: “Structure of carboxypeptidase B at 2.8 ångströms resolution”. X-ray diffraction, 2 pockets (best druggability 0.59). MolNFT v1 #3346 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1CPB
Type: protein
Length: 299 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carboxypeptidase B
EC: 3.4.17.2
UniProt: P00732
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Carboxypeptidase B (EC 3.4.17.2)	protein	82	0% helix, 0% strand	P00732
B	Carboxypeptidase B (EC 3.4.17.2)	protein	217	0% helix, 0% strand	P00732

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	263	0.59	0.77	64	empty
2	56	0.28	0.72	19	empty

Interfaces

1 interface between chains.

A–B · 738 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1CPB · Structure of carboxypeptidase B at 2.8 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
P00732 · AlphaFold monomer V2.0 prediction for carboxypeptidase B (P00732) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00732
Elsewhere: RCSB PDB 1CPB · PDBe 1CPB · UniProt P00732

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