MolNFT v1 · #33349 · protein
Replication factor C adpnp complex
2CHV · Replication factor C small subunit: “Replication factor C adpnp complex”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #33349 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2CHV
- Type
- protein
- Length
- 1,878 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replication factor C small subunit
- UniProt
- O28219
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Replication factor C small subunit | protein | 313 | 55% helix, 9% strand | O28219 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 763 | 0.81 | 0.85 | 79 | empty |
| 2 | 724 | 0.79 | 0.83 | 78 | empty |
| 3 | 909 | 0.76 | 0.79 | 90 | empty |
| 4 | 991 | 0.76 | 0.78 | 90 | empty |
| 5 | 950 | 0.75 | 0.78 | 89 | empty |
Interfaces
6 interfaces between chains.
- D–E · 1692 Ų buried · 26 hydrogen bonds · protein-protein
- A–F · 1679 Ų buried · 27 hydrogen bonds · protein-protein
- C–D · 1613 Ų buried · 24 hydrogen bonds · protein-protein
- A–B · 1486 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1156 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O28219
- Elsewhere: RCSB PDB 2CHV · PDBe 2CHV · UniProt O28219
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