MolNFT v1 · #33339 · protein
Structure of casein kinase 1 gamma 3
2CHL · Casein kinase I isoform gamma-3: “Structure of casein kinase 1 gamma 3”. X-ray diffraction, 2 ligands (DKI, SO4), 1 pocket (best druggability 0.61). MolNFT v1 #33339 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2CHL
- Type
- protein
- Length
- 298 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase I isoform gamma-3
- EC
- 2.7.1.-
- UniProt
- Q9Y6M4
- Ligands
- DKI, SO4
- Pockets
- 1 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Casein kinase I isoform gamma-3 (EC 2.7.1.-) | protein | 298 | 36% helix, 18% strand | Q9Y6M4 |
Ligands and binding sites
- DKI · 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide · ligand · chains A
- SO4 · Sulfate ion · ion · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 299 | 0.61 | 0.79 | 35 | DKI |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y6M4
- Elsewhere: RCSB PDB 2CHL · PDBe 2CHL · UniProt Q9Y6M4
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