MolNFT v1 · #33302 · protein
Crystal structure of biotin ligase from mycobacterium tuberculosis
2CGH: “Crystal structure of biotin ligase from mycobacterium tuberculosis”. X-ray diffraction, 6 pockets (best druggability 0.48). MolNFT v1 #33302 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2CGH
- Type
- protein
- Length
- 480 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Biotin ligase
- EC
- 6.3.4.15
- UniProt
- P96884
- Pockets
- 6 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Biotin ligase (EC 6.3.4.15) | protein | 238 | 31% helix, 34% strand | P96884 |
| B | Biotin ligase (EC 6.3.4.15) | protein | 242 | 31% helix, 33% strand | P96884 |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 193 | 0.48 | 0.75 | 27 | empty |
| 2 | 125 | 0.40 | 0.75 | 22 | empty |
| 3 | 82 | 0.39 | 0.77 | 15 | empty |
| 4 | 60 | 0.36 | 0.78 | 12 | empty |
| 5 | 65 | 0.33 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 881 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 2CGH · crystal structure of biotin ligase from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P96884
- Elsewhere: RCSB PDB 2CGH · PDBe 2CGH · UniProt P96884
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.