MolNFT v1 · #33213 · protein
Structure and binding kinetics of three different human CD1D-alpha-galactosylceramide-specific T cell receptors (TCR 5B)
2CDG · TCR 5E: “Structure and binding kinetics of three different human CD1D-alpha-galactosylceramide-specific T cell…”. X-ray diffraction, 4 pockets (best druggability 0.68). MolNFT v1 #33213 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2CDG
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TCR 5E
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TCR 5E | protein | 184 | 3% helix, 48% strand | — |
| B | TCR 5E | protein | 244 | 7% helix, 49% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 782 | 0.68 | 0.75 | 66 | empty |
| 2 | 95 | 0.38 | 0.76 | 19 | empty |
| 3 | 96 | 0.38 | 0.76 | 22 | empty |
| 4 | 90 | 0.34 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2203 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2CDG · Structure and binding kinetics of three different human CD1d-alpha… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2CDG · PDBe 2CDG
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