MolNFT v1 · #33131 · protein
Escrt-I core
2CAZ · Suppressor protein STP22 of temperature-sensitive alpha…: “Escrt-I core”. X-ray diffraction, 7 pockets (best druggability 0.75). MolNFT v1 #33131 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2CAZ
- Type
- protein
- Length
- 436 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Suppressor protein STP22 of temperature-sensitive alpha- factor receptor and arginine…
- UniProt
- P25604, Q02767, Q99176
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 6 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor protein STP22 of temperature-sensitive alpha- factor receptor and arginine permease | protein | 58 | 84% helix, 0% strand | P25604 |
| B | Vacuolar protein sorting-associated protein VPS28 | protein | 100 | 65% helix, 0% strand | Q02767 |
| C | Protein SRN2 | protein | 64 | 84% helix, 0% strand | Q99176 |
| D | Suppressor protein STP22 of temperature-sensitive alpha- factor receptor and arginine permease | protein | 60 | 82% helix, 0% strand | P25604 |
| E | Vacuolar protein sorting-associated protein VPS28 | protein | 101 | 60% helix, 0% strand | Q02767 |
| F | Protein SRN2 | protein | 53 | 81% helix, 0% strand | Q99176 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 846 | 0.75 | 0.79 | 72 | empty |
| 2 | 147 | 0.53 | 0.80 | 22 | empty |
| 3 | 70 | 0.51 | 0.85 | 12 | empty |
| 4 | 59 | 0.50 | 0.85 | 19 | empty |
| 5 | 110 | 0.45 | 0.78 | 15 | empty |
Interfaces
9 interfaces between chains.
- D–E · 1275 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1248 Ų buried · 7 hydrogen bonds · protein-protein
- D–F · 904 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 872 Ų buried · 6 hydrogen bonds · protein-protein
- B–E · 650 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2CAZ · ESCRT-I core · the same entry in another collection · chain F against F, TM-score 1.00
- Q02767 · AlphaFold monomer V2.0 prediction for vacuolar protein sorting- associated protein 28… · a predicted model of the same protein · chain B against A, TM-score 0.96
- P25604 · AlphaFold monomer V2.0 prediction for suppressor protein STP22 of temperature-sensitive… · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q99176 · AlphaFold monomer V2.0 prediction for protein SRN2 (Q99176) · a predicted model of the same protein · chain F against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25604
- Every structure of UniProt Q02767
- Every structure of UniProt Q99176
- Elsewhere: RCSB PDB 2CAZ · PDBe 2CAZ · UniProt P25604 · UniProt Q02767 · UniProt Q99176
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