MolNFT v1 · #33027 · protein
Crystal structure of the plp-bound form of btrr, a dual functional aminotransferase involved in butirosin biosynthesis.
2C7T · Glutamine-2-deoxy-scyllo-inosose aminotransferase: “Crystal structure of the plp-bound form of btrr, a dual functional aminotransferase involved in butirosin…”. X-ray diffraction, 2 ligands (PLP, SO4), 2 pockets (best druggability…
- PDB
- 2C7T
- Type
- protein
- Length
- 411 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine-2-deoxy-scyllo-inosose aminotransferase
- EC
- 2.6.1.-
- UniProt
- Q8G8Y2
- Ligands
- PLP, SO4
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamine-2-deoxy-scyllo-inosose aminotransferase (EC 2.6.1.-) | protein | 411 | 40% helix, 17% strand | Q8G8Y2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.51 | 0.79 | 24 | SO4 |
| 2 | 61 | 0.47 | 0.84 | 22 | PLP |
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 2C7T · Crystal structure of the plp-bound form of btrr, a dual functional aminotransferase… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8G8Y2 · AlphaFold monomer V2.0 prediction for L-GLUTAMINE:2-deoxy-scyllo- inosose… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8G8Y2
- Elsewhere: RCSB PDB 2C7T · PDBe 2C7T · UniProt Q8G8Y2
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