MolNFT v1 · #33026 · protein
Crystal structure of human protein tyrosine phosphatase kappa at 1.95A resolution
2C7S · Receptor-type tyrosine-protein phosphatase kappa: “Crystal structure of human protein tyrosine phosphatase kappa at 1.95A resolution”. X-ray diffraction, 2 pockets (best druggability 0.39). MolNFT v1 #33026 on GenesisL1: 3D…
- PDB
- 2C7S
- Type
- protein
- Length
- 289 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase kappa
- EC
- 3.1.3.48
- UniProt
- Q15262
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase kappa (EC 3.1.3.48) | protein | 289 | 37% helix, 22% strand | Q15262 |
Ligands and binding sites
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.39 | 0.76 | 22 | ACT |
| 2 | 55 | 0.30 | 0.75 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2C7S · Crystal structure of human protein tyrosine phosphatase kappa at 1.95A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q15262 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase kappa… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15262
- Elsewhere: RCSB PDB 2C7S · PDBe 2C7S · UniProt Q15262
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