MolNFT v1 · #32846 · protein
Structure and function of RV0130, a conserved hypothetical protein from M.TUBERCULOSIS
2C2I: “Structure and function of RV0130, a conserved hypothetical protein from M.TUBERCULOSIS”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #32846 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2C2I
- Type
- protein
- Length
- 298 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RV0130
- EC
- 4.2.1.17
- UniProt
- P96807
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | RV0130 (EC 4.2.1.17) | protein | 149 | 26% helix, 39% strand | P96807 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 340 | 0.72 | 0.84 | 46 | empty |
| 2 | 345 | 0.70 | 0.83 | 46 | empty |
Interfaces
1 interface between chains.
- A–B · 1700 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 2C2I · Structure and function of Rv0130, a conserved hypothetical protein from M.tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P96807
- Elsewhere: RCSB PDB 2C2I · PDBe 2C2I · UniProt P96807
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