MolNFT v1 · #32838 · protein
Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
2C2A: “Structure of the entire cytoplasmic portion of a sensor histidine kinase protein”. X-ray diffraction, 2 ligands (ADP, SO4), 2 pockets (best druggability 0.65). MolNFT v1 #32838 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2C2A
- Type
- protein
- Length
- 240 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor histidine kinase
- UniProt
- Q9WZV7
- Ligands
- ADP, SO4
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor histidine kinase | protein | 240 | 53% helix, 20% strand | Q9WZV7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 345 | 0.65 | 0.80 | 39 | ADP |
| 2 | 58 | 0.28 | 0.73 | 10 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2C2A · Structure of the entire cytoplasmic portion of a sensor histidine kinase protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZV7
- Elsewhere: RCSB PDB 2C2A · PDBe 2C2A · UniProt Q9WZV7
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