MolNFT v1 · #3273 · protein
Human cytomegalovirus protease
1CMV: “Human cytomegalovirus protease”. X-ray diffraction, 5 pockets (best druggability 0.41). MolNFT v1 #3273 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1CMV
- Type
- protein
- Length
- 403 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human cytomegalovirus protease
- EC
- 3.4.21.-
- UniProt
- P16753
- Pockets
- 5 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human cytomegalovirus protease (EC 3.4.21.-) | protein | 197 | 35% helix, 24% strand | P16753 |
| B | Human cytomegalovirus protease (EC 3.4.21.-) | protein | 206 | 38% helix, 23% strand | P16753 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.41 | 0.79 | 16 | empty |
| 2 | 73 | 0.38 | 0.78 | 17 | empty |
| 3 | 85 | 0.33 | 0.74 | 17 | empty |
| 4 | 62 | 0.31 | 0.75 | 13 | empty |
| 5 | 76 | 0.31 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1382 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1CMV · Human cytomegalovirus protease · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16753
- Elsewhere: RCSB PDB 1CMV · PDBe 1CMV · UniProt P16753
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