MolNFT v1 · #32631 · protein

Native structure of endoglucanase 12A (CEL12A) from rhodothermus marinus

2BW8: “Native structure of endoglucanase 12A (CEL12A) from rhodothermus marinus”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.45). MolNFT v1 #32631 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2BW8
Type: protein
Length: 452 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endoglucanase
EC: 3.2.1.4
UniProt: O33897
Ligands: SO4
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Endoglucanase (EC 3.2.1.4)	protein	226	7% helix, 53% strand	O33897

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.45	0.76	23	empty
2	112	0.41	0.76	23	empty

Interfaces

1 interface between chains.

A–B · 168 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2BW8 · Native structure of Endoglucanase 12A (Cel12A) from Rhodothermus marinus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O33897
Elsewhere: RCSB PDB 2BW8 · PDBe 2BW8 · UniProt O33897

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.