MolNFT v1 · #32624 · protein
Crystal structure of the hydrolase domain of human 10-formyltetrahydrofolate 2 dehydrogenase
2BW0 · 10-formyltetrahydrofolate dehydrogenase: “Crystal structure of the hydrolase domain of human 10-formyltetrahydrofolate 2 dehydrogenase”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.70). MolNFT v1 #32624 on…
- PDB
- 2BW0
- Type
- protein
- Length
- 309 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 10-formyltetrahydrofolate dehydrogenase
- EC
- 1.5.1.6
- UniProt
- O75891
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) | protein | 309 | 27% helix, 27% strand | O75891 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 451 | 0.70 | 0.81 | 49 | SO4 |
Compared structures
- 2BW0 · Crystal Structure of the hydrolase domain of Human 10-Formyltetrahydrofolate 2… · the same entry in another collection · chain A against A, TM-score 1.00
- O75891 · AlphaFold monomer V2.0 prediction for cytosolic 10-formyltetrahydrofolate dehydrogenase… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75891
- Elsewhere: RCSB PDB 2BW0 · PDBe 2BW0 · UniProt O75891
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