MolNFT v1 · #32613 · protein
Structures of three HIV-1 HLA-B5703-peptide complexes and identification of related hlas potentially associated with long-term non-progression
2BVP · HLA class I histocompatibility antigen, B-57 alpha chain: “Structures of three HIV-1 HLA-B5703-peptide complexes and identification of related hlas potentially…”. X-ray diffraction, 5 pockets (best druggability 0.70). MolNFT v1…
- PDB
- 2BVP
- Type
- protein
- Length
- 382 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, B-57 alpha chain; Beta-2-microglobulin; HIV-P24
- UniProt
- P18465, P61769
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, B-57 alpha chain | protein | 274 | 27% helix, 40% strand | P18465 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| C | HIV-P24 | protein | 9 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 599 | 0.70 | 0.79 | 50 | empty |
| 2 | 87 | 0.45 | 0.81 | 22 | empty |
| 3 | 94 | 0.42 | 0.78 | 21 | empty |
| 4 | 55 | 0.35 | 0.78 | 14 | empty |
| 5 | 61 | 0.34 | 0.77 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1295 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 867 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2BVP · Structures of Three HIV-1 HLA-B5703-Peptide Complexes and Identification of Related HLAs… · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18465
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 2BVP · PDBe 2BVP · UniProt P18465 · UniProt P61769
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