MolNFT v1 · #32591 · protein

Regulator of G-protein signalling 1 (human)

2BV1: “Regulator of G-protein signalling 1 (human)”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #32591 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2BV1
Type: protein
Length: 264 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulator of G-protein signalling 1
UniProt: Q08116
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Regulator of G-protein signalling 1	protein	134	70% helix, 3% strand	Q08116
B	Regulator of G-protein signalling 1	protein	130	69% helix, 2% strand	Q08116

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.42	0.80	15	empty
2	107	0.40	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 977 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

2BV1 · Regulator of G-protein Signalling 1 (Human) · the same entry in another collection · chain A against A, TM-score 1.00
Q08116 · AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 1 (Q08116) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08116
Elsewhere: RCSB PDB 2BV1 · PDBe 2BV1 · UniProt Q08116

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