MolNFT v1 · #32379 · protein
Crystal structure and assembly of TSP36, a metazoan small heat shock protein
2BOL: “Crystal structure and assembly of TSP36, a metazoan small heat shock protein”. X-ray diffraction, 1 ligand (SO4), 10 pockets (best druggability 0.69). MolNFT v1 #32379 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2BOL
- Type
- protein
- Length
- 591 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small heat shock protein
- UniProt
- Q7YZT0
- Ligands
- SO4
- Pockets
- 10 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Small heat shock protein | protein | 301 | 22% helix, 37% strand | Q7YZT0 |
| B | Small heat shock protein | protein | 290 | 24% helix, 37% strand | Q7YZT0 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 336 | 0.69 | 0.82 | 28 | empty |
| 2 | 365 | 0.66 | 0.80 | 26 | empty |
| 3 | 443 | 0.60 | 0.75 | 51 | empty |
| 4 | 77 | 0.58 | 0.88 | 19 | empty |
| 5 | 93 | 0.56 | 0.86 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3288 Ų buried · 42 hydrogen bonds · protein-protein
Compared structures
- 2BOL · Crystal structure and assembly of TSP36, a metazoan small heat shock protein · the same entry in another collection · chain A against A, TM-score 1.00
- Q7YZT0 · AlphaFold monomer V2.0 prediction for small heat shock protein P36 (Q7YZT0) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7YZT0
- Elsewhere: RCSB PDB 2BOL · PDBe 2BOL · UniProt Q7YZT0
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