MolNFT v1 · #3237 · protein

Anti-carcinoembryonic antigen monoclonal antibody A5B7

1CLO · A5B7 monoclonal antibody: “Anti-carcinoembryonic antigen monoclonal antibody A5B7”. X-ray diffraction, 4 pockets (best druggability 0.59). MolNFT v1 #3237 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1CLO
Type: protein
Length: 435 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: A5B7 monoclonal antibody
UniProt: P01868
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	A5B7 monoclonal antibody	protein	213	6% helix, 54% strand	—
H	A5B7 monoclonal antibody	protein	222	4% helix, 49% strand	P01868

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	342	0.59	0.77	50	empty
2	77	0.53	0.85	21	empty
3	315	0.53	0.74	48	empty
4	68	0.32	0.75	17	empty

Interfaces

1 interface between chains.

L–H · 1807 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1CLO · Anti-carcinoembryonic antigen monoclonal antibody A5B7 · the same entry in another collection · chain L against L, TM-score 1.00
P01868 · AlphaFold monomer V2.0 prediction for ig gamma-1 chain C region secreted form (P01868) · a predicted model of the same protein · chain H against A, TM-score 0.51

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01868
Elsewhere: RCSB PDB 1CLO · PDBe 1CLO · UniProt P01868

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