MolNFT v1 · #32090 · protein
Monoclonal antibody fragment FV4155 from E. COLI
2BFV: “Monoclonal antibody fragment FV4155 from E. COLI”. X-ray diffraction, 1 ligand (STG), 3 pockets (best druggability 0.50). MolNFT v1 #32090 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2BFV
- Type
- protein
- Length
- 231 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FV4155
- UniProt
- P01631
- Ligands
- STG
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | FV4155 | protein | 112 | 3% helix, 47% strand | P01631 |
| H | FV4155 | protein | 119 | 5% helix, 55% strand | — |
Ligands and binding sites
- STG · Estriol 3-(B-D-glucuronide) · ligand · chains L, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.50 | 0.78 | 22 | STG |
| 2 | 121 | 0.44 | 0.77 | 25 | empty |
| 3 | 90 | 0.33 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 849 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01631
- Elsewhere: RCSB PDB 2BFV · PDBe 2BFV · UniProt P01631
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