MolNFT v1 · #31974 · protein

Cholesterol esterase from bos taurus

2BCE: “Cholesterol esterase from bos taurus”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #31974 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2BCE
Type: protein
Length: 532 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cholesterol esterase
EC: 3.1.1.13
UniProt: P30122
Pockets: 4 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cholesterol esterase (EC 3.1.1.13)	protein	532	39% helix, 17% strand	P30122

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	611	0.69	0.77	37	empty
2	174	0.53	0.79	23	empty
3	51	0.36	0.80	17	empty
4	60	0.33	0.77	18	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2BCE · Cholesterol esterase from bos taurus · the same entry in another collection · chain A against A, TM-score 1.00
P30122 · AlphaFold monomer V2.0 prediction for bile salt-activated lipase (P30122) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30122
Elsewhere: RCSB PDB 2BCE · PDBe 2BCE · UniProt P30122

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