MolNFT v1 · #31960 · protein
Crystal structure of MC159 reveals molecular mechanism of disc assembly and vflip inhibition
2BBZ · Viral CASP8 and fadd-like apoptosis regulator: “Crystal structure of MC159 reveals molecular mechanism of disc assembly and vflip inhibition”. X-ray diffraction, 11 pockets (best druggability 0.84). MolNFT v1 #31960 on GenesisL1: 3D…
- PDB
- 2BBZ
- Type
- protein
- Length
- 760 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Viral CASP8 and fadd-like apoptosis regulator
- UniProt
- Q98325
- Pockets
- 11 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Viral CASP8 and fadd-like apoptosis regulator | protein | 190 | 54% helix, 0% strand | Q98325 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.84 | 0.92 | 55 | empty |
| 2 | 74 | 0.67 | 0.93 | 26 | empty |
| 3 | 71 | 0.66 | 0.92 | 20 | empty |
| 4 | 74 | 0.66 | 0.92 | 25 | empty |
| 5 | 136 | 0.42 | 0.75 | 14 | empty |
Interfaces
6 interfaces between chains.
- C–D · 722 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 684 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 625 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 557 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 557 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2BBZ · Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q98325
- Elsewhere: RCSB PDB 2BBZ · PDBe 2BBZ · UniProt Q98325
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