MolNFT v1 · #31888 · protein
Crystal structure of FUS3 with a docking motif from MSG5
2B9I · Mitogen-activated protein kinase FUS3: “Crystal structure of FUS3 with a docking motif from MSG5”. X-ray diffraction, 2 ligands (ADP, MG), 4 pockets (best druggability 0.62). MolNFT v1 #31888 on GenesisL1: 3D structure, binding…
- PDB
- 2B9I
- Type
- protein
- Length
- 352 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase FUS3; Tyrosine-protein phosphatase MSG5
- EC
- 2.7.1.37, 3.1.3.48
- UniProt
- P16892
- Ligands
- ADP, MG
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase FUS3 (EC 2.7.1.37) | protein | 338 | 39% helix, 14% strand | P16892 |
| C | Tyrosine-protein phosphatase MSG5 (EC 3.1.3.48) | protein | 14 | 21% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 268 | 0.62 | 0.80 | 35 | MG, ADP |
| 2 | 67 | 0.44 | 0.82 | 20 | empty |
| 3 | 79 | 0.36 | 0.76 | 23 | empty |
| 4 | 57 | 0.28 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–C · 787 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2B9I · Crystal structure of Fus3 with a docking motif from Msg5 · the same entry in another collection · chain A against A, TM-score 1.00
- P16892 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase FUS3 (P16892) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16892
- Elsewhere: RCSB PDB 2B9I · PDBe 2B9I · UniProt P16892
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