MolNFT v1 · #31850 · protein
Copa ATP binding domain
2B8E · Cation-transporting ATPase: “Copa ATP binding domain”. X-ray diffraction, 4 pockets (best druggability 0.70). MolNFT v1 #31850 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2B8E
- Type
- protein
- Length
- 741 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cation-transporting ATPase
- UniProt
- O29777
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cation-transporting ATPase | protein | 246 | 39% helix, 26% strand | O29777 |
| B | Cation-transporting ATPase | protein | 241 | 37% helix, 26% strand | O29777 |
| C | Cation-transporting ATPase | protein | 254 | 41% helix, 26% strand | O29777 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 603 | 0.70 | 0.79 | 57 | empty |
| 2 | 535 | 0.70 | 0.80 | 49 | empty |
| 3 | 478 | 0.68 | 0.79 | 51 | empty |
| 4 | 56 | 0.28 | 0.74 | 11 | empty |
Interfaces
2 interfaces between chains.
- A–B · 477 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 280 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O29777
- Elsewhere: RCSB PDB 2B8E · PDBe 2B8E · UniProt O29777
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