MolNFT v1 · #31829 · protein
Crystal structure of the S. cerevisiae exocyst component EXO70P
2B7M · Exocyst complex component EXO70: “Crystal structure of the S. cerevisiae exocyst component EXO70P”. X-ray diffraction, 6 pockets (best druggability 0.69). MolNFT v1 #31829 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2B7M
- Type
- protein
- Length
- 2,074 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Exocyst complex component EXO70
- UniProt
- P19658
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Exocyst complex component EXO70 | protein | 513 | 69% helix, 0% strand | P19658 |
| B | Exocyst complex component EXO70 | protein | 523 | 70% helix, 0% strand | P19658 |
| C | Exocyst complex component EXO70 | protein | 518 | 71% helix, 0% strand | P19658 |
| D | Exocyst complex component EXO70 | protein | 520 | 70% helix, 0% strand | P19658 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 421 | 0.69 | 0.80 | 40 | empty |
| 2 | 438 | 0.68 | 0.80 | 42 | empty |
| 3 | 140 | 0.49 | 0.78 | 20 | empty |
| 4 | 104 | 0.39 | 0.75 | 22 | empty |
| 5 | 97 | 0.36 | 0.74 | 19 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1229 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1214 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 106 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 52 modified (engineered).
Compared structures
- 2B7M · Crystal Structure of the S. cerevisiae Exocyst Component Exo70p · the same entry in another collection · chain A against A, TM-score 1.00
- P19658 · AlphaFold monomer V2.0 prediction for exocyst complex component EXO70 (P19658) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19658
- Elsewhere: RCSB PDB 2B7M · PDBe 2B7M · UniProt P19658
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