MolNFT v1 · #31820 · protein
Yeast guanine nucleotide exchange factor EEF1BALPHA K205A mutant in complex with EEF1A
2B7C · Elongation factor 1-alpha: “Yeast guanine nucleotide exchange factor EEF1BALPHA K205A mutant in complex with EEF1A”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #31820 on GenesisL1: 3D structure, binding sites…
- PDB
- 2B7C
- Type
- protein
- Length
- 527 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor 1-alpha; Elongation factor-1 beta
- UniProt
- P02994, P32471
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongation factor 1-alpha | protein | 437 | 22% helix, 35% strand | P02994 |
| B | Elongation factor-1 beta | protein | 90 | 19% helix, 46% strand | P32471 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1096 | 0.78 | 0.80 | 99 | empty |
| 2 | 177 | 0.58 | 0.82 | 26 | empty |
| 3 | 246 | 0.57 | 0.79 | 48 | empty |
| 4 | 127 | 0.40 | 0.74 | 19 | empty |
| 5 | 62 | 0.39 | 0.80 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1817 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 2B7C · Yeast guanine nucleotide exchange factor eEF1Balpha K205A mutant in complex with eEF1A · the same entry in another collection · chain A against A, TM-score 1.00
- P32471 · AlphaFold monomer V2.0 prediction for elongation factor 1-beta (P32471) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P02994 · AlphaFold monomer V2.0 prediction for elongation factor 1-alpha (P02994) · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02994
- Every structure of UniProt P32471
- Elsewhere: RCSB PDB 2B7C · PDBe 2B7C · UniProt P02994 · UniProt P32471
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