MolNFT v1 · #31757 · protein
Structural basis for UTP specificity of RNA editing tutases from trypanosoma brucei
2B56 · RNA editing complex protein MP57: “Structural basis for UTP specificity of RNA editing tutases from trypanosoma brucei”. X-ray diffraction, 3 ligands (U5P, UTP, MG), 1 pocket (best druggability 0.71). MolNFT v1 #31757 on GenesisL1…
- PDB
- 2B56
- Type
- protein
- Length
- 444 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA editing complex protein MP57
- UniProt
- Q86MV5
- Ligands
- U5P, UTP, MG
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA editing complex protein MP57 | protein | 444 | 46% helix, 14% strand | Q86MV5 |
Ligands and binding sites
- U5P · Uridine-5'-monophosphate · ligand · 2 copies · chains A
- UTP · Uridine 5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 631 | 0.71 | 0.79 | 52 | MG, UTP, U5P |
Compared structures
- 2B56 · Structural Basis for UTP Specificity of RNA Editing TUTases From Trypanosoma Brucei · the same entry in another collection · chain A against A, TM-score 1.00
- Q86MV5 · AlphaFold monomer V2.0 prediction for terminal uridylyltransferase 2 (Q86MV5) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86MV5
- Elsewhere: RCSB PDB 2B56 · PDBe 2B56 · UniProt Q86MV5
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