MolNFT v1 · #31723 · protein

BCL-xl 3D domain swapped dimer

2B48 · Apoptosis regulator BCL-X: “BCL-xl 3D domain swapped dimer”. X-ray diffraction, 2 pockets (best druggability 0.54). MolNFT v1 #31723 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2B48
Type: protein
Length: 143 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apoptosis regulator BCL-X
UniProt: Q07817
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apoptosis regulator BCL-X	protein	143	72% helix, 0% strand	Q07817

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	251	0.54	0.76	28	empty
2	81	0.37	0.76	17	empty

Compared structures

2B48 · Bcl-XL 3D Domain Swapped Dimer · the same entry in another collection · chain A against A, TM-score 1.00
Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07817
Elsewhere: RCSB PDB 2B48 · PDBe 2B48 · UniProt Q07817

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.