MolNFT v1 · #31677 · protein

Structure of transcription-repair coupling factor

2B2N: “Structure of transcription-repair coupling factor”. X-ray diffraction, 2 ligands (NA, SO4), 5 pockets (best druggability 0.79). MolNFT v1 #31677 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2B2N
Type: protein
Length: 617 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription-repair coupling factor
UniProt: P30958
Ligands: NA, SO4
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription-repair coupling factor	protein	308	40% helix, 19% strand	P30958
B	Transcription-repair coupling factor	protein	309	40% helix, 18% strand	P30958

Ligands and binding sites

NA · Sodium ion · metal · 3 copies · chains A, B
SO4 · Sulfate ion · ion · chains B
P4C · O-acetaldehydyl-hexaethylene glycol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1017	0.79	0.81	100	P4C
2	62	0.37	0.79	20	empty
3	66	0.33	0.76	19	empty
4	62	0.27	0.72	15	empty
5	62	0.26	0.73	12	empty

Interfaces

1 interface between chains.

A–B · 1118 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

2B2N · Structure of transcription-repair coupling factor · the same entry in another collection · chain A against A, TM-score 1.00
P30958 · AlphaFold monomer V2.0 prediction for transcription-repair-coupling factor (P30958) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30958
Elsewhere: RCSB PDB 2B2N · PDBe 2B2N · UniProt P30958

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