MolNFT v1 · #31668 · protein

Cloning, expression, characterisation and three- dimensional structure determination of the caenorhabditis elegans spermidine synthase

2B2C: “Cloning, expression, characterisation and three- dimensional structure determination of the caenorhabditis…”. X-ray diffraction, 8 pockets (best druggability 0.82). MolNFT v1 #31668 on GenesisL1: 3D structure, binding sites and…

PDB: 2B2C
Type: protein
Length: 552 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spermidine synthase
EC: 2.5.1.16
UniProt: Q9U2F0
Pockets: 8 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Spermidine synthase (EC 2.5.1.16)	protein	276	30% helix, 31% strand	Q9U2F0

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.82	0.98	22	empty
2	356	0.62	0.78	46	empty
3	312	0.61	0.79	45	empty
4	164	0.58	0.82	15	empty
5	104	0.39	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 1657 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

2B2C · Cloning, expression, characterisation and three- dimensional structure determination of… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9U2F0
Elsewhere: RCSB PDB 2B2C · PDBe 2B2C · UniProt Q9U2F0

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