MolNFT v1 · #31664 · protein
The crystal structure of the protein complex of yeast HSP40 SIS1 and HSP70 SSA1
2B26 · SIS1 protein: “The crystal structure of the protein complex of yeast HSP40 SIS1 and HSP70 SSA1”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #31664 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2B26
- Type
- protein
- Length
- 433 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SIS1 protein; Heat shock 70 kda protein cognate 2
- UniProt
- P25294, P11146
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 4 distinct chains · 11% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SIS1 protein | protein | 157 | 10% helix, 45% strand | P25294 |
| B | SIS1 protein | protein | 147 | 13% helix, 41% strand | P25294 |
| C | SIS1 protein | protein | 122 | 11% helix, 30% strand | P25294 |
| D | Heat shock 70 kda protein cognate 2 | protein | 7 | 0% helix, 29% strand | P11146 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.51 | 0.81 | 20 | empty |
| 2 | 98 | 0.42 | 0.77 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1068 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 374 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2B26 · The crystal structure of the protein complex of yeast Hsp40 Sis1 and Hsp70 Ssa1 · the same entry in another collection · chain D against D, TM-score 1.00
- P25294 · AlphaFold monomer V2.0 prediction for protein SIS1 (P25294) · a predicted model of the same protein · chain B against A, TM-score 0.97
- P11146 · AlphaFold monomer V2.0 prediction for heat shock 70 kda protein cognate 2 (P11146) · a predicted model of the same protein · chain D against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25294
- Every structure of UniProt P11146
- Elsewhere: RCSB PDB 2B26 · PDBe 2B26 · UniProt P25294 · UniProt P11146
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