MolNFT v1 · #31582 · protein

DNA mismatch repair protein muth from E. COLI

2AZO: “DNA mismatch repair protein muth from E. COLI”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #31582 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2AZO
Type: protein
Length: 445 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Muth
UniProt: P06722
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Muth	protein	218	33% helix, 21% strand	P06722
B	Muth	protein	227	27% helix, 21% strand	P06722

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	393	0.61	0.77	35	empty
2	210	0.56	0.79	26	empty
3	251	0.50	0.74	31	empty

Interfaces

1 interface between chains.

A–B · 848 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

2AZO · DNA mismatch repair protein muth from E. COLI · the same entry in another collection · chain A against A, TM-score 1.00
P06722 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein muth (P06722) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06722
Elsewhere: RCSB PDB 2AZO · PDBe 2AZO · UniProt P06722

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