MolNFT v1 · #31577 · protein

Crystal structure for the mutant D81C of sulfolobus solfataricus hexaprenyl pyrophosphate synthase

2AZJ · Geranylgeranyl pyrophosphate synthetase: “Crystal structure for the mutant D81C of sulfolobus solfataricus hexaprenyl pyrophosphate synthase”. X-ray diffraction, 4 pockets (best druggability 0.82). MolNFT v1 #31577 on GenesisL1: 3D…

PDB: 2AZJ
Type: protein
Length: 550 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Geranylgeranyl pyrophosphate synthetase
EC: 2.5.1.1
Pockets: 4 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.1)	protein	276	78% helix, 1% strand	—
B	Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.1)	protein	274	77% helix, 0% strand	—

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	936	0.82	0.84	74	empty
2	146	0.77	0.93	18	empty
3	355	0.64	0.79	35	empty
4	73	0.39	0.78	15	empty

Interfaces

1 interface between chains.

A–B · 1859 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

2AZJ · Crystal structure for the mutant D81C of Sulfolobus solfataricus hexaprenyl pyrophosphate… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2AZJ · PDBe 2AZJ

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