GL1X · GenesisL1 explorer

MolNFT v1 · #31563 · protein + RNA

Flock house virus B2-dsrna complex (P212121)

2AZ0 · 5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)…: “Flock house virus B2-dsrna complex (P212121)”. X-ray diffraction, 1 pocket (best druggability 0.65). MolNFT v1 #31563 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
2AZ0
Type
protein + RNA
Length
177 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU) P*CP*CP*AP*(5BU)P*GP*C)-3'; B2 protein
UniProt
P68831
Pockets
1 · best druggability 0.65

Structure

x-ray diffraction · 3 distinct chains · 79% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
C, D5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU) P*CP*CP*AP*(5BU)P*GP*C)-3'rna18——
AB2 proteinprotein7079% helix, 0% strandP68831
BB2 proteinprotein7180% helix, 0% strandP68831

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
16470.650.7631empty

Interfaces

6 interfaces between chains.

  • A–B · 1481 Ų buried · 10 hydrogen bonds · protein-protein
  • C–D · 865 Ų buried · 79 hydrogen bonds · nucleic-nucleic
  • C–B · 398 Ų buried · 9 hydrogen bonds · protein-nucleic
  • D–A · 378 Ų buried · 9 hydrogen bonds · protein-nucleic
  • D–B · 333 Ų buried · 7 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 6 modified (nucleotide modification).

Compared structures

  • 2AZ0 · Flock House virus B2-dsRNA Complex (P212121) · the same entry in another collection · chain C against C, TM-score 1.00

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