MolNFT v1 · #31513 · protein
Crystal structures of T cell receptor beta chains related to rheumatoid arthritis
2AXJ · SF4 T cell receptor beta chain: “Crystal structures of T cell receptor beta chains related to rheumatoid arthritis”. X-ray diffraction, 4 pockets (best druggability 0.61). MolNFT v1 #31513 on GenesisL1: 3D structure, binding sites…
- PDB
- 2AXJ
- Type
- protein
- Length
- 484 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SF4 T cell receptor beta chain
- UniProt
- Q6GMR4
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SF4 T cell receptor beta chain | protein | 242 | 5% helix, 48% strand | Q6GMR4 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 347 | 0.61 | 0.78 | 48 | empty |
| 2 | 198 | 0.53 | 0.78 | 29 | empty |
| 3 | 127 | 0.40 | 0.75 | 26 | empty |
| 4 | 61 | 0.28 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1779 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2AXJ · Crystal structures of T cell receptor beta chains related to rheumatoid arthritis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GMR4
- Elsewhere: RCSB PDB 2AXJ · PDBe 2AXJ · UniProt Q6GMR4
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