MolNFT v1 · #31317 · protein

Crystal structure of human adenylate kinase 4, AK4

2AR7: “Crystal structure of human adenylate kinase 4, AK4”. X-ray diffraction, 3 pockets (best druggability 0.79). MolNFT v1 #31317 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2AR7
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenylate kinase 4
EC: 2.7.4.3
UniProt: P27144
Pockets: 3 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Adenylate kinase 4 (EC 2.7.4.3)	protein	221	48% helix, 14% strand	P27144

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	891	0.79	0.81	94	empty
2	185	0.52	0.78	21	empty
3	63	0.41	0.81	16	empty

Interfaces

1 interface between chains.

A–B · 1088 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

2AR7 · Crystal structure of human adenylate kinase 4, AK4 · the same entry in another collection · chain A against A, TM-score 1.00
P27144 · AlphaFold monomer V2.0 prediction for adenylate kinase 4, mitochondrial (P27144) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27144
Elsewhere: RCSB PDB 2AR7 · PDBe 2AR7 · UniProt P27144

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