MolNFT v1 · #31195 · protein
Crystal structure of the P332G mutant of the bacillus subtilis nos
2AN0 · Nitric oxide synthase: “Crystal structure of the P332G mutant of the bacillus subtilis nos”. X-ray diffraction, 1 ligand (HEM), 3 pockets (best druggability 0.78). MolNFT v1 #31195 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2AN0
- Type
- protein
- Length
- 361 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nitric oxide synthase
- EC
- 1.14.13.39
- UniProt
- O34453
- Ligands
- HEM
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nitric oxide synthase (EC 1.14.13.39) | protein | 361 | 42% helix, 14% strand | O34453 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 650 | 0.78 | 0.83 | 52 | HEM |
| 2 | 103 | 0.42 | 0.77 | 19 | empty |
| 3 | 91 | 0.38 | 0.76 | 17 | empty |
Compared structures
- 2AN0 · Crystal Structure of the P332G mutant of the Bacillus subtilis NOS · the same entry in another collection · chain A against A, TM-score 1.00
- O34453 · AlphaFold monomer V2.0 prediction for nitric oxide synthase oxygenase (O34453) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O34453
- Elsewhere: RCSB PDB 2AN0 · PDBe 2AN0 · UniProt O34453
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