MolNFT v1 · #31186 · protein
Loose dimer of a bacillus subtilis nitric oxide synthase
2AMO · Nitric oxide synthase oxygenase: “Loose dimer of a bacillus subtilis nitric oxide synthase”. X-ray diffraction, 1 ligand (HEM), 6 pockets (best druggability 0.79). MolNFT v1 #31186 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2AMO
- Type
- protein
- Length
- 724 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nitric oxide synthase oxygenase
- EC
- 1.14.13.39
- UniProt
- O34453
- Ligands
- HEM
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Nitric oxide synthase oxygenase (EC 1.14.13.39) | protein | 362 | 42% helix, 15% strand | O34453 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 865 | 0.79 | 0.82 | 73 | HEM |
| 2 | 735 | 0.78 | 0.82 | 66 | HEM |
| 3 | 76 | 0.51 | 0.84 | 19 | empty |
| 4 | 104 | 0.38 | 0.75 | 17 | empty |
| 5 | 77 | 0.35 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 63 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O34453
- Elsewhere: RCSB PDB 2AMO · PDBe 2AMO · UniProt O34453
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