MolNFT v1 · #31160 · protein

Aldehyde reductase

2ALR: “Aldehyde reductase”. X-ray diffraction, 4 pockets (best druggability 0.55). MolNFT v1 #31160 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ALR
Type: protein
Length: 312 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aldehyde reductase
EC: 1.1.1.2
UniProt: P14550
Pockets: 4 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aldehyde reductase (EC 1.1.1.2)	protein	312	38% helix, 20% strand	P14550

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	201	0.55	0.78	27	empty
2	73	0.50	0.84	22	empty
3	104	0.43	0.78	21	empty
4	90	0.33	0.74	17	empty

Compared structures

2ALR · Aldehyde reductase · the same entry in another collection · chain A against A, TM-score 1.00
P14550 · AlphaFold monomer V2.0 prediction for aldo-keto reductase family 1 member A1 (P14550) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14550
Elsewhere: RCSB PDB 2ALR · PDBe 2ALR · UniProt P14550

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