MolNFT v1 · #31136 · protein
The structure of bovine B-lactoglobulin a in crystals grown at very low ionic strength
2AKQ · Beta-lactoglobulin variant a: “The structure of bovine B-lactoglobulin a in crystals grown at very low ionic strength”. X-ray diffraction, 8 pockets (best druggability 0.62). MolNFT v1 #31136 on GenesisL1: 3D structure, binding…
- PDB
- 2AKQ
- Type
- protein
- Length
- 624 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-lactoglobulin variant a
- UniProt
- P02754
- Pockets
- 8 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Beta-lactoglobulin variant a | protein | 156 | 17% helix, 39% strand | P02754 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 368 | 0.62 | 0.78 | 40 | empty |
| 2 | 87 | 0.51 | 0.83 | 15 | empty |
| 3 | 76 | 0.48 | 0.83 | 19 | empty |
| 4 | 97 | 0.48 | 0.81 | 19 | empty |
| 5 | 77 | 0.47 | 0.82 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 574 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 296 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 18 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2AKQ · The structure of bovine B-lactoglobulin A in crystals grown at very low ionic strength · the same entry in another collection · chain A against A, TM-score 1.00
- P02754 · AlphaFold monomer V2.0 prediction for beta-lactoglobulin (P02754) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02754
- Elsewhere: RCSB PDB 2AKQ · PDBe 2AKQ · UniProt P02754
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.