MolNFT v1 · #30975 · protein

The solution structure of type II antifreeze protein reveals a new member of the lectin family

2AFP · Protein (sea raven type II antifreeze protein): “The solution structure of type II antifreeze protein reveals a new member of the lectin family”. Solution nmr, 2 pockets (best druggability 0.66). MolNFT v1 #30975 on GenesisL1: 3D…

PDB: 2AFP
Type: protein
Length: 129 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (sea raven type II antifreeze protein)
UniProt: P05140
Pockets: 2 · best druggability 0.66

Structure

solution nmr · 1 distinct chain · 16% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (sea raven type II antifreeze protein)	protein	129	16% helix, 11% strand	P05140

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	153	0.66	0.87	32	empty
2	103	0.41	0.77	22	empty

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

2AFP · The solution structure of type II antifreeze protein reveals a new member of the lectin… · the same entry in another collection · chain A against A, TM-score 1.00
P05140 · AlphaFold monomer V2.0 prediction for type-2 ice-structuring protein (P05140) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05140
Elsewhere: RCSB PDB 2AFP · PDBe 2AFP · UniProt P05140

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