MolNFT v1 · #30919 · protein

Tropinone reductase-II

2AE1: “Tropinone reductase-II”. X-ray diffraction, 1 pocket (best druggability 0.72). MolNFT v1 #30919 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2AE1
Type: protein
Length: 252 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tropinone reductase-II
EC: 1.1.1.236
UniProt: P50163
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tropinone reductase-II (EC 1.1.1.236)	protein	252	49% helix, 16% strand	P50163

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	646	0.72	0.79	57	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2AE1 · Tropinone reductase-II · the same entry in another collection · chain A against A, TM-score 1.00
P50163 · AlphaFold monomer V2.0 prediction for tropinone reductase 2 (P50163) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50163
Elsewhere: RCSB PDB 2AE1 · PDBe 2AE1 · UniProt P50163

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.