MolNFT v1 · #3070 · protein
Complex recognition of the supertypic BW6-determinant on HLA-B and-C molecules by the monoclonal antibody SFR8-B6
1CG9 · Protein (HLA class I histocompatibility antigen, B-35 B*…: “Complex recognition of the supertypic BW6-determinant on HLA-B and-C molecules by the monoclonal antibody…”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT…
- PDB
- 1CG9
- Type
- protein
- Length
- 386 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (HLA class I histocompatibility antigen, B-35 B* 3501 alpha chain); Protein…
- UniProt
- P30685, P61769, P03204
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (HLA class I histocompatibility antigen, B-35 B* 3501 alpha chain) | protein | 277 | 29% helix, 40% strand | P30685 |
| B | Protein (beta-2-microglobulin) | protein | 100 | 0% helix, 49% strand | P61769 |
| C | Protein (ebna-6 nuclear protein (ebna-3C) (ebna-4B)) | protein | 9 | 0% helix, 0% strand | P03204 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 531 | 0.67 | 0.78 | 54 | empty |
| 2 | 120 | 0.42 | 0.76 | 15 | empty |
| 3 | 51 | 0.30 | 0.76 | 13 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1409 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 853 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1CG9 · Complex recognition of the supertypic BW6-determinant on HLA-B and-C molecules by the… · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30685
- Every structure of UniProt P61769
- Every structure of UniProt P03204
- Elsewhere: RCSB PDB 1CG9 · PDBe 1CG9 · UniProt P30685 · UniProt P61769 · UniProt P03204
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