MolNFT v1 · #30615 · protein

Crystal structure of mouse cadherin-11 EC1

2A4C: “Crystal structure of mouse cadherin-11 EC1”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #30615 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2A4C
Type: protein
Length: 198 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cadherin-11
UniProt: P55288
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cadherin-11	protein	99	3% helix, 46% strand	P55288

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.61	0.90	16	empty
2	66	0.49	0.85	17	empty
3	66	0.47	0.84	17	empty

Interfaces

1 interface between chains.

A–B · 1267 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

2A4C · Crystal structure of mouse cadherin-11 EC1 · the same entry in another collection · chain A against A, TM-score 1.00
P55288 · AlphaFold monomer V2.0 prediction for cadherin-11 (P55288) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55288
Elsewhere: RCSB PDB 2A4C · PDBe 2A4C · UniProt P55288

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