MolNFT v1 · #30555 · protein

Crystal structure of a putative pyridoxine 5'-phosphate oxidase (RV2607) from mycobacterium tuberculosis

2A2J · Pyridoxamine 5'-phosphate oxidase: “Crystal structure of a putative pyridoxine 5'-phosphate oxidase (RV2607) from mycobacterium tuberculosis”. X-ray diffraction, 3 pockets (best druggability 0.80). MolNFT v1 #30555 on GenesisL1: 3D…

PDB: 2A2J
Type: protein
Length: 406 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pyridoxamine 5'-phosphate oxidase
EC: 1.4.3.5
UniProt: P65682
Pockets: 3 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5)	protein	203	31% helix, 34% strand	P65682

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	614	0.80	0.85	74	empty
2	607	0.79	0.85	70	empty
3	87	0.65	0.91	20	empty

Interfaces

1 interface between chains.

A–B · 2611 Å² buried · 36 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (artifact).

Compared structures

2A2J · Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P65682
Elsewhere: RCSB PDB 2A2J · PDBe 2A2J · UniProt P65682

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