MolNFT v1 · #30536 · protein
Human phytanoyl-CoA 2-hydroxylase in complex with iron and 2- oxoglutarate
2A1X · Phytanoyl-CoA dioxygenase: “Human phytanoyl-CoA 2-hydroxylase in complex with iron and 2- oxoglutarate”. X-ray diffraction, 2 ligands (AKG, FE2), 1 pocket (best druggability 0.66). MolNFT v1 #30536 on GenesisL1: 3D structure…
- PDB
- 2A1X
- Type
- protein
- Length
- 253 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phytanoyl-CoA dioxygenase
- EC
- 1.14.11.18
- UniProt
- O14832
- Ligands
- AKG, FE2
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phytanoyl-CoA dioxygenase (EC 1.14.11.18) | protein | 253 | 26% helix, 28% strand | O14832 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 417 | 0.66 | 0.79 | 38 | FE2, AKG |
Compared structures
- 2A1X · Human phytanoyl-coa 2-hydroxylase in complex with iron and 2-oxoglutarate · the same entry in another collection · chain A against A, TM-score 1.00
- O14832 · AlphaFold monomer V2.0 prediction for phytanoyl-CoA dioxygenase, peroxisomal (O14832) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14832
- Elsewhere: RCSB PDB 2A1X · PDBe 2A1X · UniProt O14832
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