MolNFT v1 · #30297 · protein
The DNA-bound solution structure of HPV-16 E2 DNA-binding domain
1ZZF · Regulatory protein E2: “The DNA-bound solution structure of HPV-16 E2 DNA-binding domain”. Solution nmr, 4 pockets (best druggability 0.67). MolNFT v1 #30297 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1ZZF
- Type
- protein
- Length
- 162 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulatory protein E2
- UniProt
- P03120
- Pockets
- 4 · best druggability 0.67
Structure
solution nmr · 1 distinct chain · 31% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Regulatory protein E2 | protein | 81 | 31% helix, 40% strand | P03120 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.67 | 0.95 | 21 | empty |
| 2 | 74 | 0.58 | 0.88 | 22 | empty |
| 3 | 121 | 0.50 | 0.80 | 17 | empty |
| 4 | 117 | 0.50 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 872 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 1ZZF · The DNA-bound solution structure of HPV-16 E2 DNA-binding domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03120
- Elsewhere: RCSB PDB 1ZZF · PDBe 1ZZF · UniProt P03120
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.