MolNFT v1 · #30291 · protein
Crystal structure of feii hppe
1ZZ9 · Hydroxypropylphosphonic acid epoxidase: “Crystal structure of feii hppe”. X-ray diffraction, 2 ligands (FE2, SO4), 6 pockets (best druggability 0.65). MolNFT v1 #30291 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1ZZ9
- Type
- protein
- Length
- 575 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hydroxypropylphosphonic acid epoxidase
- EC
- 1.14.-.-
- UniProt
- Q56185
- Ligands
- FE2, SO4
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hydroxypropylphosphonic acid epoxidase (EC 1.14.-.-) | protein | 192 | 24% helix, 29% strand | Q56185 |
| B | Hydroxypropylphosphonic acid epoxidase (EC 1.14.-.-) | protein | 193 | 28% helix, 31% strand | Q56185 |
| C | Hydroxypropylphosphonic acid epoxidase (EC 1.14.-.-) | protein | 190 | 25% helix, 26% strand | Q56185 |
Ligands and binding sites
- FE2 · Fe (II) ion · metal · 3 copies · chains A, B, C
- SO4 · Sulfate ion · ion · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 395 | 0.65 | 0.79 | 42 | FE2 |
| 2 | 410 | 0.62 | 0.77 | 37 | empty |
| 3 | 307 | 0.61 | 0.79 | 37 | FE2 |
| 4 | 107 | 0.47 | 0.79 | 16 | FE2 |
| 5 | 145 | 0.42 | 0.75 | 28 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1531 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 184 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 29 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q56185
- Elsewhere: RCSB PDB 1ZZ9 · PDBe 1ZZ9 · UniProt Q56185
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