MolNFT v1 · #30149 · protein
Eosfp fluorescent protein- green form
1ZUX · Green to red photoconvertible gpf-like protein eosfp: “Eosfp fluorescent protein- green form”. X-ray diffraction, 1 ligand (CR8), 12 pockets (best druggability 0.82). MolNFT v1 #30149 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1ZUX
- Type
- protein
- Length
- 876 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Green to red photoconvertible gpf-like protein eosfp
- Ligands
- CR8
- Pockets
- 12 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Green to red photoconvertible gpf-like protein eosfp | protein | 219 | 5% helix, 57% strand | — |
Ligands and binding sites
- CR8 · 2-[1-amino-2-(1H-imidazol-5-yl)ethyl]-1-(carboxymethyl)-4-[(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-1H-imidazol-5-olate · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1170 | 0.82 | 0.84 | 77 | empty |
| 2 | 75 | 0.75 | 0.98 | 23 | CR8 |
| 3 | 74 | 0.74 | 0.98 | 24 | CR8 |
| 4 | 70 | 0.74 | 0.98 | 24 | CR8 |
| 5 | 74 | 0.74 | 0.98 | 26 | CR8 |
Interfaces
5 interfaces between chains.
- A–B · 1229 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1193 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 1040 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 1037 Ų buried · 29 hydrogen bonds · protein-protein
- B–C · 13 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 covalent (covalent ligand).
Compared structures
- 1ZUX · EosFP Fluorescent Protein- Green Form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1ZUX · PDBe 1ZUX
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