MolNFT v1 · #30141 · protein
Structure of human ubiquitin-conjugating enzyme (ubci) involved in embryo attachment and implantation
1ZUO · Hypothetical protein LOC92912: “Structure of human ubiquitin-conjugating enzyme (ubci) involved in embryo attachment and implantation”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #30141 on GenesisL1: 3D…
- PDB
- 1ZUO
- Type
- protein
- Length
- 302 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein LOC92912
- EC
- 6.3.2.19
- UniProt
- Q8WVN8
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein LOC92912 (EC 6.3.2.19) | protein | 162 | 41% helix, 21% strand | Q8WVN8 |
| B | Hypothetical protein LOC92912 (EC 6.3.2.19) | protein | 140 | 37% helix, 24% strand | Q8WVN8 |
Ligands and binding sites
- BME · Beta-mercaptoethanol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.67 | 0.91 | 19 | empty |
| 2 | 54 | 0.32 | 0.77 | 13 | empty |
| 3 | 67 | 0.30 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 698 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (additive adduct).
Compared structures
- 1ZUO · Structure of Human Ubiquitin-Conjugating Enzyme (UBCi) Involved in Embryo Attachment and… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WVN8 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 Q2 (Q8WVN8) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WVN8
- Elsewhere: RCSB PDB 1ZUO · PDBe 1ZUO · UniProt Q8WVN8
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