MolNFT v1 · #30074 · protein
Beta pix-SH3 complexed with an atypical peptide from alpha-pak
1ZSG · Rho guanine nucleotide exchange factor 7: “Beta pix-SH3 complexed with an atypical peptide from alpha-pak”. Solution nmr, 1 pocket (best druggability 0.47). MolNFT v1 #30074 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1ZSG
- Type
- protein
- Length
- 87 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho guanine nucleotide exchange factor 7; SERINE/THREONINE-protein kinase pak 1
- EC
- 2.7.1.37
- UniProt
- Q14155, Q13153
- Pockets
- 1 · best druggability 0.47
Structure
solution nmr · 2 distinct chains · 0% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho guanine nucleotide exchange factor 7 | protein | 65 | 0% helix, 43% strand | Q14155 |
| B | SERINE/THREONINE-protein kinase pak 1 (EC 2.7.1.37) | protein | 22 | 0% helix, 0% strand | Q13153 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.47 | 0.84 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 579 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1ZSG · beta PIX-SH3 complexed with an atypical peptide from alpha-PAK · the same entry in another collection · chain A against A, TM-score 1.00
- Q14155 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 7 (Q14155) · a predicted model of the same protein · chain A against A, TM-score 0.77
- Q13153 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase pak 1 (Q13153) · a predicted model of the same protein · chain B against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14155
- Every structure of UniProt Q13153
- Elsewhere: RCSB PDB 1ZSG · PDBe 1ZSG · UniProt Q14155 · UniProt Q13153
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