MolNFT v1 · #30047 · protein
Crystal structure of eba-175 region II (rii) crystallized in the presence of (ALPHA)2,3-sialyllactose
1ZRO · Erythrocyte binding antigen region II: “Crystal structure of eba-175 region II (rii) crystallized in the presence of (ALPHA)2,3-sialyllactose”. X-ray diffraction, 2 ligands (SO4, CL), 17 pockets (best druggability 0.81). MolNFT v1…
- PDB
- 1ZRO
- Type
- protein
- Length
- 1,176 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Erythrocyte binding antigen region II
- UniProt
- Q25735
- Ligands
- SO4, CL
- Pockets
- 17 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 64% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Erythrocyte binding antigen region II | protein | 588 | 64% helix, 3% strand | Q25735 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1016 | 0.81 | 0.82 | 82 | SO4 |
| 2 | 1054 | 0.81 | 0.82 | 90 | SO4 |
| 3 | 646 | 0.72 | 0.79 | 68 | SO4 |
| 4 | 614 | 0.71 | 0.79 | 60 | SO4 |
| 5 | 130 | 0.64 | 0.87 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1756 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 26 disulfide (disulfide).
Compared structures
- 1ZRO · Crystal structure of EBA-175 Region II (RII) crystallized in the presence of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q25735
- Elsewhere: RCSB PDB 1ZRO · PDBe 1ZRO · UniProt Q25735
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